Programmed Cell Death, Cell Proliferation, and Cancer Biology
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Researchers
Joel Rothman
Regulation of development and differentiation; regulation of programmed cell death and cell division; mechanisms of tumorigenesis
Pradeep Joshi
My research investigates the apoptotic and non-apoptotic roles of programmed cell death (PCD) regulators during cellular growth, proliferation, reprogramming and mitochondrial purifying selection in the C. elegans germline. I am also investigating the role of mitochondria and hormesis in aging and longevity as well as the regulation of adult germline stem cell (GSC) homeostasis by microRNAs.
Cricket Wood
I participate in and support several different research projects within the lab while managing the day to day running of the lab.
Juwel Chandra Baray
My research is centered on understanding transdifferentiation, transorganogenesis, and the intriguing fields of aging and longevity in the nematode C. elegans. Furthermore, my objective is to bridge the gap between human biology and model organisms by applying these insights to the context of human cells.
Nicholas De Leon
I am currently working with and assisting PJ and Cricket on the Longevity Screen. This project utilizes the genetic properties of C.elegans as a model organism to study the mechanisms that influence aging and how these mechanisms regulate lifespan.
Ella Finch
I am working with Juwel to investigate if partial reprogramming of C. elegans using transcription factors will halt aging and increase longevity. The end goal of these experiments is to apply these findings to humans and reduce molecular hallmarks of aging.
Jake Shiro
I work with Cricket and Dr. Joshi on a longevity screen searching for dominant mutations in C. elegans. We hope to find homologous genes in humans to help slow the aging process and extend lifespan.